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administration and one involved once-weekly intravenous (i.v.) administration [13]

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Downstream: IRS-1 Tyr-612/896 phosphorylation PI3K p110 PIP3 PDK1 Akt Thr-308 (1.8-2.4 baseline within 30 minutes) and Akt Ser-473 (mTORC2-dependent, 1.4-1.8 at 45 minutes)