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Remarkably, GLP-1Rs are highly expressed in various tissues, including pancreatic cells, brain, endothelium, lung, GIT, kidneys, and immune cells (Baggio and Drucker 2021)

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By reducing NMDA excitotoxicity, Pinealon could help preserve penumbral tissue during the critical hours following stroke onset

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5.4.2 Pharmacological Advances Mirogabalin New gabapentinoid approved in Japan with higher 2- subunit affinity than pregabalin, offering improved pain relief and tolerability [139]