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Activation of the Nrf2 pathway was found to diminish liver injury due to iron overload by regulating the expression of Tf and FTH and reducing the accumulation of cellular iron-free ions, thereby inhibiting oxidative stress and attenuating cell death [47]

Significantly increased activities of both AST and ALT in our experiment suggest an adverse effect of 8 days of water-only fasting on the functional state of the liver, but the lack of changes in the De Ritis index did not confirm this

It also lowers cholesterol, as we had demonstrated and published from Saskatchewan in 1955

10.3892/ijo.2015.3240 11 BaekJ.-S.NaY.-G.ChoC.-W

Online 51 , 105042 (2025)

In contrast, oridonin alone did not demonstrate sufficient efficacy at the same dosage