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All but one of these five people has hyperuricemia, but not everyone gets gout [1]

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And prostaglandin E2 (PGE2) could promote the pro-inflammatory M1-like macrophage polarization, which refers to the killer-polarization state in which macrophages exert the cell cytotoxic function and IL-8 could recruit the neutrophils (27)

However, this is not a systematic review

A systematic review published in the Journal of Drugs in Dermatology (2019), analyzing 11 studies involving over 800 participants, concluded that oral collagen peptide supplementation is well-tolerated , with adverse effects that are rare and generally mild (Choi et al., 2019)

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