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Studies (36,37) have also demonstrated that NF-B is a downstream mediator of PPAR and PPAR signaling in the liver, which is supported by our findings that increased expression levels of NF-B p65 are inhibited by pioglitazone, a specific agonist of PPAR

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Additionally, PAR2-dependent signaling has been implicated in promoting weight gain and metabolic inflammation in mouse models of diet-induced obesity (DIO) (23), but the specific proteases by which PAR2 signaling exerts metabolic inflammation and DIO remain unclear (24)

7 Antioxidant Properties : The mogrosides in monk fruit have been shown to have antioxidant properties, which help to reduce oxidative stress and inflammation in the body

Pain reduction: WOMAC pain scores dropped by up to 75.8% (4.5 points)