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Retatrutide shows the highest weight loss in trials (28.7%), followed by tirzepatide (25%)

Be sure to follow the plan recommended by your healthcare provider

They also help control blood glucose levels, reducing the amount of subcutaneous fat your body stores

PT-141 is contraindicated in patients with uncontrolled hypertension

Peer review Peer review information Nature Chemistry thanks Daniel Reker and the other, anonymous, reviewer(s) for their contribution to the peer review of this work