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After FOXO4-DRI treatment, the staining of FOXO4 and p53-pS15 became weaker in the nucleus at 48 h and then disappeared with an accumulation in the cytoplasm at 72 h, especially in keloid fibroblasts

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GHK-Cu is a complex of copper and glycyl-l-histidyl-l-lysine (GHK), a peptide present in human plasma, saliva, and urine that decreases in concentration as we age

In turn, we speculated that this impairment of mitochondrial metabolism in FoB might explain the increase in aerobic glycolysis for ATP production

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Because these symptoms can overlap with other health concerns, its important for families to reach out to their healthcare provider at Family Health Care if any of these issues arise