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When GPX4 is inhibited (for example, by RSL3) or when System Xc becomes dysfunctional, GSH levels are depleted (27, 28) (Figure 2)

Furthermore, Western blot results also indicated that the supernatant of tumor cells treated with NP4 promoted TRPM2 protein expression in macrophages (Fig

16, 46, 47 Moreover, current data further demonstrated that genetic manipulation of acetyl-CoA carboxylase 1 (ACC1) or acetyl-CoA carboxylase 2 (ACC2) in cancer cells yielded different outcomes in terms of FAS and FAO