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as described by Falanga and colleagues, TfR is expressed highly in bone marrow, immune system, and female tissues, moderately in brain, endocrine tissues, lung, gastrointestinal tract, kidney, urinary bladder, male tissues, and skin, and low in muscle tissues, liver, gallbladder, adipose, and soft tissue, aside from serum [21]

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This, in turn, can result in B12 deficiency

Hepatic methionine homeostasis is conserved in C57BL/6N mice on high-fat diet despite major changes in hepatic one-carbon metabolism