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Experimental models of anoxia/reoxygenation injury demonstrated that larazotide preserves epithelial barrier integrity by maintaining transepithelial electrical resistance and preventing the disassembly of tight junction components such as ZO-1, occludin, and claudins

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The effect is modest at the individual level but statistically robust across nearly 28,000 patients and replicated in an independent NIH All of Us cohort

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