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This observation raises the possibility of direct anti-inflammatory or central effects

Typically, most people start to notice gradual weight loss between weeks 5 and 9, but this can vary depending on the individual

It also feeds into the GABA shunt, an alternative metabolic pathway that produces Gamma-aminobutyric acid (GABA), the brain's primary inhibitory neurotransmitter

Patients can remain on these medications indefinitely, and the clinical data supporting long-term use extends to multiple years

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