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[DOI] [PubMed] [Google Scholar] [100].Fujino S, Andoh A, Bamba S, Ogawa A, Hata K, Araki Y, et al

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Research peptides in this space fall into two distinct mechanistic categories: GHRH analogs (e.g., CJC-1295, Sermorelin, Tesamorelin ) bind the GHRH receptor on pituitary somatotrophs to directly stimulate GH synthesis and release GHRPs / Ghrelin mimetics (e.g., Ipamorelin, GHRP-2, GHRP-6, Hexarelin) bind the GHS-R1a receptor to amplify GH release through a separate, complementary pathway Ipamorelin falls firmly in the GHRP/ghrelin mimetic category

The decision to retract comes two years after Science first raised allegations of manipulation in 2022