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While these lifestyle strategies generally dont produce effects as large as prescription GLP-1 medications, they can be an important part of improving metabolic health and may benefit many people

Over the years, methods have been refined into the most commonly used protocol today, which uses an acid/ethanol precipitation (to disrupt the IGF-1/IGFBP complex) followed by the addition of insulin-like growth factor-2 (IGF-2) to prevent the reformation of the IGF/IGFBP complex

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Kang EA, Han YM, An JM, Park YJ, Sikiric P, Kim DH, et al

Curr Opin Chem Biol