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Adequate B12 ensures the oxygen and nutrients are available for follicles to respond effectively to this stimulation

TLR4-associated IRF-7 and NFB signaling act as a molecular link between androgen and metformin activities and cytokine synthesis in the PCOS endometrium

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These FFAs further activate inflammatory pathways, including nuclear factor-B and c-Jun N-terminal kinase, amplifying cytokine production and sustaining a self-perpetuating cycle of inflammation and metabolic dysfunction [19]

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