Exposure to xenobiotics, heavy metals (such as lead, mercury, and arsenic), stress, poor dietary choices, toxic cocktails of prescription and non-prescription drugs, trauma, and infections all have huge consequences for the body and its ability to maintain adequate glutathione levels
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Standard protocols use 0.25-0.5 mg (250-500 mcg) daily via subcutaneous injection
Under normal conditions, Nrf2 is anchored in the cytosol through its interaction with Kelch-like ECH-associated protein 1 (Keap1), which serves as a substrate adapter protein for an E3 ubiquitin ligase complex (Zhang et al
However, a low B12 level wont determine the cause of the deficiency, so further testing may be needed
Proc Natl Acad Sci (2003) 100:94405
