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Biochem Biophys Res Commun (2012) 424(2):3216.10.1016/j.bbrc.2012.06.116 Summary Keywords glutathione S -transferases P, phosphorylation, high mobility group box-1 protein, classic protein kinase C, sepsis Citation Zhou Y, Cao X, Yang Y, Wang J, Yang W, Ben P, Shen L, Cao P, Luo L and Yin Z (2018) Glutathione S -Transferase Pi Prevents Sepsis-Related High Mobility Group Box-1 Protein Translocation and Release
Procyanidins appears to modulate autophagy in aging or oxidative stress conditions by regulating FoxO1 suppression or PI3K-Akt pathway activation, potentially promoting ROS clearance (Zhou S
doi: 10.1038/s41593-020-00789-y 31 Van HoveHMartensLScheyltjensIDe VlaminckKPombo AntunesARDe PrijckSet al
The results are consistently positive and the mechanistic data is compelling, but as of 2026 there are no completed Phase 3 human randomized controlled trials
RESULTS NAPQI Cytotoxicity NAPQI cytotoxicity studies were performed for each cell line to determine the extent of interindividual variation in IC 50 values as a measure of NAPQI toxicity and as a phenotype for association studies designed to identify potential biomarkers for the prediction of toxicity risk