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Weeks 17 onward: 12 mg weekly

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Other GLP-1 medications could follow suit for approvals, with a meta-analysis showing that GLP-1 agonists significantly reduced the risk of serious kidney complications in people with Type 2 diabetes

Int J Neurosci 133(5):473491

By targeting the brains appetite centers, retatrutide reduces hunger and increases feelings of fullness, leading to decreased calorie intake