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GLP-1 has glucose concentration dependent hypoglycemic effect

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Interestingly, Pycnogenol intake in osteoarthritis patients reduced gene expression of key catabolic and inflammation markers like MMP-3, MMP-13 and IL-1 by more than 50% within knee cartilage (71)

The question of which one works better depends on several factors, including how each drug works in the body and what health goals matter most to you

doi: 10.1016/j.jasms.2010.08.001