Visceral fat and IGF-1 are meaningful measures, but they are surrogate/intermediate endpoints, not hard clinical outcomes like cardiovascular events
However, short-term use is less common because discontinuing the medication often leads to weight regain if lifestyle changes are not sustained
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Importantly, expression levels of these genes have been used in numerous studies as sensitive indices for oxidative stress 8,19,20
Furthermore, WB analysis was conducted on extracts from the aortas of aging mice, showing consistent results with in vitro experiments: increased expression of p-P53 and decreased expression of total P53 after FOXO4-DRI treatment
+ If you are genuinely low in B12, an injection can lift the fatigue, brain fog and sluggishness that deficiency causes, which many people feel as a clear energy boost