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Trial SELECT (Lincoff et al., NEJM 2023) Design Phase 3 / 39.8 mo mean follow-up Population 17,604 adults with CVD + overweight or obesity, no diabetes Key result 20% reduction in major heart events (HR 0.80

Tirzepatide is a newer medication and is still being assessed for its long-term effects and potential additional benefits, such as cardiovascular outcomes

The most promising compounds, 39 and 40 (Figure 6), showed an IC 50 of 2.80 nM against DPP-4 catalytic activity, with 20 - 40-fold selectivity over the DPP-8 and DPP-9 isozymes

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