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10.1093/ije/dyv301 347

The nervous system withstands ageing better than other organs and systems (a phenomenon recognised long ago 516 ), which arguably reflects the high plastic potential allowing constant remodelling of the nervous tissue (the process which underlines life-long learning and adaptation) and high defensive and regenerative potential of neuroglia defining nervous system resilience and regeneration mending various insults accumulating during life-span

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Combining it with other antioxidants like vitamin C and E can create synergistic effects

Role of roasting conditions in the level of chlorogenic acid content in coffee beans: correlation with coffee acidity

Some manufacturers recommend a dose between 600 and 1200 mg injected once or twice weekly, though research does not support this