10.3389/fchem.2022.964662 [DOI] [PMC free article] [PubMed] [Google Scholar] Yu M., Alimujiang M., Hu L., Liu F., Bao Y., Yin J
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For example, some gut microbes have the ability to remove iodine atoms in hormones, which may lead to the inhibition of the synthesis and secretion of thyroid hormones (Khrle et al., 1987)
Therefore, the constipation is missed by parents and doctors alike
Various rodent models manifesting PCOS-like traits can be induced through the administration of diverse drugs and szintetikus hormones, including androgens containing dihydrotestosterone (DHT), testosterone (T), and dehydroepiandrosterone (DHEA), estrogen, as well as aromatase inhibitors ( Furthermore, the utilization of a combination of antibiotics, comprising vancomycin hydrochloride, ampicillin sodium, neomycin sulfate, and metronidazole, has exhibited effectiveness in eliminating the indigenous gut microbiota of the host ( Thus, our investigation endeavored to make model of a pseudo germ-free PCOS mouse through the application of letrozole and antibiotics, with the aim of allowing insight into the gut microbiotas influence on the regulation of metabolic and reproductive phenotypes in mice with PCOS
They are derived from patterns observed across hundreds of trial participants and from the pharmacological profile of the drug
