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Do not use GLP-1 if you or any of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC) or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Do not use GLP-1 if you have had a serious allergic reaction to semaglutide or tirzepatide or any of the ingredients in GLP-1

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Here, we critically appraise ESSENCE from clinical and translational perspectives and consider the relative contributions of weight loss vs