Diagnostic biomarkers for B12 status include decreased levels of circulating total B12 and transcobalamin-bound B12, and abnormally increased levels of homocysteine and methylmalonic acid
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( A ) Schematic of isotope tracing with labeled [ 15 N, 13 C 5 ]valine
described a strong correlation between the antioxidant activity of polyphenols and their affinity for Fe(II) ions, suggesting that the suppression of the Fenton reaction is probably due to ion chelation [93]
Similarly, this goal may be achieved by the supplementation of pro-glutathione compounds, which easily permeate into the cell, e.g., glutathione monoethylester (GSH-OEt), I-152 (which is a codrug of NAC and S -acetyl- -mercaptoethylamine), S -acetylglutathione, N -butanoylglutathione, and GSH-C4 [60,65,70]