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AMPK-mediated BECN1 phosphorylation promotes ferroptosis by directly blocking system xc(-) activity
Notably, over 99% of the glutathione produced was in the reduced, biologically active form
Since AsA may donate a hydrogen atom to generate a relatively stable ascorbyl-free radical, it provides first line of defense against oxidative damage to proteins and lipid membranes
It should be noted that changes in other lipid species that are relevant to liver injury and inflammation, such as acyl-CoAs, diacylglycerides, ceramides and sphingolipids 42 , were not investigated in the present study