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Diagnostic methods such as GC/MS became more widely available in the 1980s and later so that the patients with IEMs were diagnosed with an IEM instead of Reyes syndrome

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The compound's interaction with GABA receptors and nitric oxide signaling provides a protective effect against oxidative stress-induced neuronal damage

In life-threatening cases, 5,000,000mcg of B12 is given directly to the veins within a 15 minute window

& Croce, C