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One-third of patients achieved clinically significant weight loss, defined as 5% change from baseline

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The TRANSCEND-T2D-1 trial demonstrated A1C reductions of up to 2.0% and weight loss of up to 16.8% at 40 weeks, with no plateau observed through the end of the treatment period

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doi: 10.1016/j.molcel.2018.03.018 36 PuckettDLAlquraishiMChowanadisaiWBettaiebA