Insulin resistance was determined by calculating the homeostatic model assessment for insulin resistance (HOMA-IR) as follows: ((fasting glucose fasting insulin)/22.5) after adjusting for units
rxlist.com (Byetta ) rxlist.com (Byduron ) extended release formulation Keywords Liraglutide Trade Names: Victoza & generic Pharmacology: GLP-1 analog mechanism of action is the same as exenatide Indications: an adjunct to diet and exercise to improve glycemic control in type 2 diabetes mellitus to reduce the risk of major adverse cardiovascular events (cardiovascular death, non-fatal myocardial infarction, or non-fatal stroke) in adults with type 2 diabetes mellitus and established cardiovascular disease Pharmacokinetics: once-daily injection Side Effects: Most common : nausea, diarrhea, vomiting (similar to exenatide) Black Box Warning: RISK OF THYROID C-CELL TUMORS References: Masharani U, Kroon L (2024): Pancreatic Hormones & Antidiabetic Drugs (Chapter 41)
Retatrutide is only being studied as a once-weekly injection
Once commercially available (expected late 2026-2027), brand-name retatrutide pricing will likely mirror or exceed tirzepatide pricing, given Eli Lilly manufactures both compounds and the market dynamics of premium obesity medications
We expect TRIUMPH-1 to confirm these metabolic benefits in a larger population
This is simply because Ozempic drug trials focused on how it impacted blood sugar (like metformin does), while Wegovy drug trials focused on how it impacted weight
