tirzepatide in south africa Mounjaro/Zepbound Drastically Cuts Risk Of Type 2 Diabetes, Eli Lilly Report Suggests Worth The Weight: Medicine's Gold

What they found: Favorable safety profile , no serious adverse events at doses up to 100 g/kg Preliminary efficacy signals positive The program stopped before Phase 3 for unknown commercial reasons (the program passed through several sponsor rotations and no one ultimately carried it through) Why it matters: These are the only published clinical data in humans that we have

Gene expression analysis showed upregulation of survival pathways (Egr1, Akt1, Kras, Src, Foxo, Srf, VEGFR2, NOS1, NOS3) and downregulation of inflammatory mediators (NOS2, NFB)

Accessed Apr 1, 2025

Dandona P, Chaudhuri A, Ghanim H, Mohanty P

Overall survival probability was analyzed through Kaplan Meier curves (median cut) and significance calculated through log rank analysis

showed that the overexpression of miR-19b-3p from ADSC-Exos can directly target iron regulatory protein, resulting in decreased neurological damage and intracerebral haemorrhage caused by ferroptosis [141]