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Outside the CNS, changes in insulin levels can affect CNS dopaminergic signaling, and insulin resistance may further contribute to dopamine-mediated inflammation and depressive symptoms (Kleinridders et al., 2015

doi: 10.3389/fmicb.2022.967851 Received 13 June 2022 Accepted 27 June 2022 Published 01 August 2022 Volume 13 - 2022 Edited by Xiancan Zhu, Anhui Normal University, China Reviewed by Pandiyan Muthuramalingam, Gyeongsang National University, South Korea

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a ) Data are presented as box plots min-max (median), cytosolic fraction at 3 M, tGSH ( Trkb Penk-WT 1.0 0.03