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In the Sibutramine Cardiovascular Outcomes (SCOUT) trial, the drug was shown to be associated with increased risk of major adverse cardiovascular events (a composite of non-fatal heart attack, non-fatal stroke, resuscitation after cardiac arrest, and cardiovascular death) in obese patients, as compared to placebo [29]

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Interestingly, the immunological phenomenon of original antigenic sin, where immune responses to subsequent similar but nonidentical antigens are dominated by less effective cross-reactive immunity rather than generating de novo highly specific and effective immunity, has been described for influenza

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