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When mitochondrial function becomes impaired, ROS production may increase while energy production becomes less efficient

Hexokinase 2 (HK2), the first rate-limiting enzyme of glycolysis, was recently identified as a critical target

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This might ascertain a relation of close-to-normal functioning with high-serum lithium or potassium, or low-serum potassium [105,106], rather than the disturbed function that may be expected

In preclinical heart failure models, NNMT enzyme inhibition markedly reduced cardiac 1-MNA (by 77.1%), improved cardiac function, reduced left ventricular hypertrophy and fibrosis, and decreased pro-inflammatory gene expression