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Selegiline/Modafinil (Focus/Energy Aids) Mechanism: Stimulant/activating agents alter arousal and wakefulness circuits

As described in our summary of the foundational 2007 Pyo et al

Compound 24 (Figure 21) demonstrated dose-dependent COX-2 inhibition and selectivity in successive enzymatic assays and reduced COX-2 expression in the peripheral blood cells of CIA rats

Experimental investigations suggest that it may interact with telomerase activity and influence melatonin production

Benefits begin fading 4 to 8 weeks after stopping

About a dozen Navy personnel were treated for smoke inhalation after a fan malfunctioned on the USS Harpers Ferry, an aging warship docked at General Dynamics NASSCO shipyard in San Diego as it undergoes a $64 million repair and modernization project