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Im grateful to have worked with a fantastic study team and collaborators on this important question

Semaglutide lowers body weight in rodents via distributed neural pathways

Obesity is a chronic condition like high blood pressure, elevated cholesterol or high blood sugar and requires chronic treatment, said lead author Dr

This makes it different from earlier compounds that mainly focused on one pathway

The peptide mimetic DPP-4 inhibitors including vildagliptin, saxagliptin and teneligliptin, were identified by peptide-based substrate substitution experiments, while the non-peptide mimetic group such as sitagliptin, alogliptin and linagliptin, were derived from the inhibitor and initially found in random screening

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