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Conversely, Melatonin, investigated for its potential antioxidant effects, failed to demonstrate significant improvement in outcomes for STEMI patients undergoing PCI in the MARI trial ( The overall mixed clinical results for exogenous antioxidants underscore significant challenges in translating preclinical success, largely contributing to their unmet promise. These hurdles include poor pharmacokinetics and bioavailability, leading to insufficient concentrations at the injury site, and a critical lack of specificity

Low levels of colonic glutathione and glutathione S-transferase activity are associated with a high risk for development of colorectal cancer [96]

Additionally, maximal respiratory rates and reserve capacity, measured in the presence of the mitochondrial uncoupler CCCP, were larger after sUA+LPS stimulus in Nlrp3 deficiency, but not in Myd88 / and WT macrophages (Fig