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The metabolic pathways of these precursors are shown in Figure 1

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However, researchers noted several limitations, including the single-centre, retrospective design, reliance on chart abstraction rather than validated disease activity indices, and the possibility of residual confounding

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Therefore, we think that the downregulation of signal pathways such as PKA or PKC is, at least in part, involved in the ineffectiveness of GLP-1RA on the -cell function at an advanced stage