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The longer the medication stays in contact with the sublingual membrane, the more compound crosses into your bloodstream

These findings underscore the importance of considering demographic factors when evaluating the safety and efficacy of GLP-1 RAs in clinical practice

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For example, we observed that both GLP-1 and its presumed inert metabolite GLP-1(936) showed coronary and mesenteric artery vasodilation, as well as cardioprotection from IRI ex vivo, in isolated tissues from both WT and Glp1r -KO ( Glp1r / ) mice, whereas the nondegradable GLP-1R agonist exenatide did not have these effects in the absence of a functional GLP-1R (4, 21)

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