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Generic manufacturers can demonstrate bioequivalence with a relatively standardized pharmacokinetic study in healthy volunteers, and the FDA can rely on the innovators clinical data for safety and efficacy

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(2017) demonstrated sustained ADHD symptom reduction over 12 to 13 hours in a laboratory classroom setting, with effect sizes that remained consistent from morning through early evening [1]

The two have distinct half-life and receptor-binding profiles in published research

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However, the efficacy of these methods fails to satisfy the demands of patient prognosis