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NR1H4 not only controls intestinal barrier integrity, prevents bacterial translocation, maintains gut microbiota homeostasis, but also regulates the expression of genes involved in cholesterol and bile acid homeostasis, hepatic gluconeogenesis, adipogenesis, inflammation, and fibrosis [73]

Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers

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