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Exclusion criteria were a history of bariatric surgery, alcohol use disorder identification test (AUDIT) greater than 16, hemoglobin A1c measurement greater than 9, a history of seizure disorder or traumatic brain injury, on specific medications that interfere with alcohol metabolism such as certain antibiotics (reviewed on a case-by-case basis by study physician), or currently pregnant or lactating

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TRIUMPH-5 and TRIUMPH-6 TRIUMPH-5 is an active-comparator trial in type 2 diabetes, benchmarking retatrutide against an existing GLP-1 rather than placebo

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Insurance coverage may also play a role for those seeking retatrutide as part of a medical treatment plan, especially as the medication moves through clinical trials and toward potential FDA approval

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