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These medications are contraindicated in patients with active multiple endocrine neoplasia type 2 or with a personal or family history of medullary thyroid carcinoma

High concentrations of IGF-I were associated with an increased risk of prostate cancer (odds ratio comparing 75th with 25th percentile 149, 95% CI 114195) and premenopausal breast cancer (165, 126208) and high concentrations of IGFBP-3 were associated with increased risk of pre-menopausal breast cancer (151, 101227)

The peak HR increase mirrored the PK profile, which shows that the maximum plasma concentration of exenatide is reached 2 h after injection [20]