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In adolescent male rat models exposed by the Delta-9-tetrahydrocannabinol (THC), L-theanine could strongly block the development of emotional and cognitive abnormalities associated with adolescent THC exposure, since L-theanine pretreatment could intercept THC-induced downregulation of local GSK-3 and Akt signaling pathway in the prefrontal cortex (PFC) (54)

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