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Is GLP-1 therapy appropriate given health status

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However, since NO is freely diffusible across membranes, it is possible that the mitochondrial production of peroxynitrite may derive from extramitochondrial NO diffusing into mitochondria to react with superoxide generated by ETC

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Furthermore, studies have demonstrated that the therapeutic effects of GLP-1RAs and GLP-1/GLP-2 receptor dual agonists against myocardial ischemia/reperfusion injury are, at least partially, dependent on EAT regulation (99)