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Effects of GLP-1 receptor agonists and SGLT-2 inhibitors on cardiac structure and function: a narrative review of clinical evidence

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Muscle atrophy in patients with type 2 diabetes mellitus: roles of inflammatory pathways, physical activity and exercise

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Retatrutide (LY3437943) represents a major advance in this direction as a synthetic peptide designed to simultaneously activate GLP-1R, GIPR, and GCGR [2,3]

Hence, if retatrutide acted by stimulation of adenylyl cyclase, then an inhibition of this cyclase by carbachol and PIA would explain the negative inotropic effect of carbachol and PIA in the presence of retatrutide