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The herpes simplex virus 1 protein kinase encoded by the US3 gene mediates posttranslational modification of the phosphoprotein encoded by the UL34 gene

This weight loss occurs through multiple mechanisms including reduced caloric intake, delayed gastric emptying, and possible effects on energy expenditure

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5.4 Pharmacological effects of SIN in other diseases SIN has exhibited therapeutic efficacy in various diseases, including colitis (119), atherosclerosis (120), myocardial ischemiareperfusion injury (100), chronic sciatic nerve injury (CCI) (121), renal injury (122), colorectal cancer (123), lung cancer, liver cancer, cervical cancer, bladder cancer, gastric cancer, and renal cancer (93, 124, 125)

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