Ferroptotic pores induce Ca 2+ fluxes and ESCRT-III activation to modulate cell death kinetics
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doi: 10.2139/ssrn.5087025 3 GuarnieriJWHaltomJAAlbrechtYESLieTOlaliAZWidjajaGAet al
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During fetal and early postnatal life, adequate maternal thyroid hormone supply is critical for neurogenesis, neuronal migration, synaptogenesis, and myelination ( The entry of thyroid hormones into the central nervous system depends on specialized transporters at the BBB ( Within the brain, deiodinase enzymes modulate local hormone availability ( At the cellular level, thyroid hormones act through nuclear receptors TR and TR to regulate transcription of genes involved in neuronal metabolism, mitochondrial biogenesis, and cytoskeletal organization ( 3.2 Hypothyroidism and central nervous system dysfunction Hypothyroidism affects the central nervous system in ways that extend beyond metabolic slowing
