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PIONEER 2 to 4 used the same FAS and SAS described above, in addition to a per protocol (PP) analysis set

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P2Y 2 receptor agonists, denufosol (OLIYNYK et al., 2010), were promising for their ability to activate alternative chloride secretion pathways, but both of these agonists have not been pursued further due to not meeting primary study goals of improving FEV 1 (Ratjen et al., 2012) and having a narrow effective concentration range, respectively (OLIYNYK et al., 2010)

It can be taken at a consistent time each day and used alongside other supplements depending on personal preference

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