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[15] [16] It is worth noting that these energy improvements typically develop gradually over weeks to months as metabolic changes occur, rather than immediately after starting treatment

This recognition inappropriately activates the immune system, triggering pathological inflammation via the cytosolic c-GAS-STING sensing pathway, leading to aberrant cytokine expression and proinflammatory immune cell recruitment in diabetes (Riley and Tait, 2020)

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