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Zhang W, Yang S, He H, Liu C, Chen W, Tang X

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Action of capsaicin on dorsal root-evoked synaptic transmission to substantia gelatinosa neurons in adult rat spinal cord slices

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A 2015 paper shows that the influenza A virus directly activates mast cells, causing the release of cytokines and contributing to the excessive inflammatory response in the lungs.[ref] Animal studies show that this pattern of mast cell activation and excessive response holds true for several flu strains