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At baseline, the children had higher concentrations of galactose intermediates, N-acetylserotonin and trimethylamine N-oxide, and lower concentrations of selenium and 3-hydroxybutyrate than the control group

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Mechanistically, increased ECM stiffness activates integrin-mediated mechanotransduction pathways, notably the focal adhesion kinase (FAK), RhoA/ROCK, and YAP/TAZ signaling cascades (151)

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doi: 10.1006/taap.1995.1204